Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)

Gastrointestinal Cancers Ferroptosis, necroptosis, and pyroptosis all contributed to the development of gastrointestinal cancers. The inactivation of GPX4 or inhibition of System Xc- can result in ferroptosis due to the accumulation of lipid peroxides. The binding of cell surface death receptors and ZBP1 could trigger the necrosis. Interaction of PAMP and DAMP with pattern recognition receptors on the cell surface triggers the classical pyroptosis pathway. More details can be found in article number 2300824 by Xudong Zhu and Shenglong Li.