Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells
Source abstract
Abstract
Abstract Forming tight interaction with both Purkinje and granule cells (GCs), Bergmann glia (BG) are essential for cerebellar morphogenesis and neuronal homeostasis. However, how BG act in this process is unclear without comprehensive transcriptome landscape of BG. Here, high temporal‐resolution investigation of transcriptomes with FACS‐sorted BG revealed the dynamic expression of genes within given functions and pathways enabled BG to assist neural migration and construct neuron‐glia network. It is found that the peak time of GCs migration (P7‐10) strikingly coincides with the downregulation of extracellular matrix (ECM) related genes, and the disruption of which by Setdb1 ablation at P7‐10 in BG leads to significant migration defect of GCs emphasizing the criticality of Nfix‐Setdb1 mediated H3K9me3 repressive complex for the precise regulation of GCs migration in vivo. Thus, BG's transcriptomic landscapes offer an insight into the mechanism by which BG are in depth integrated in cerebellar neural network.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Neurogenesis and neuroplasticity mechanisms · RNA Research and Splicing · Epigenetics and DNA Methylation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Cellular Stress Biology The First Affiliated Hospital of Xiamen University School of Life Sciences Xiamen University Xiamen 361102 China
The Department of Neuroscience School of Medicine Xiamen University Xiamen 361102 China
Xiang'an Hospital of Xiamen University School of Medicine Xiamen 361102 China
National Institute for Data Science in Health and Medicine Xiamen University Xiamen 361102 China
Key Laboratory of Ministry of Education for Coast and Wetland Ecosystems College of the Environment and Ecology Xiamen University Xiamen 361102 China
Department of Clinical Laboratory Fujian Provincial Hospital Fuzhou 350001 China
Provincial Clinical College Fujian Medical University Fuzhou 350001 China
Funding
Fundamental Research Funds for the Central Universities
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