Limb Development: Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture (Adv. Sci. 23/2020)

Zi Yin; Junxin Lin; Ruojin Yan; Richun Liu; Mengfei Liu; Bo Zhou; Wenyan Zhou; Chengrui An; Yangwu Chen; Yejun Hu; Chunmei Fan; Kun Zhao; Bingbing Wu; Xiaohui Zou; Jin Zhang; Ahmed H. El‐Hashash; Xiao Chen; Hongwei Ouyang

doi:10.1002/advs.202070129

journal article·2020-12Open access

Limb Development: Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture (Adv. Sci. 23/2020)

Zi Yin, Junxin Lin, Ruojin Yan, Richun Liu, Mengfei Liu, Bo Zhou, Wenyan Zhou, Chengrui An, Yangwu Chen, Yejun Hu, Chunmei Fan, Kun Zhao, Bingbing Wu, Xiaohui Zou, Jin Zhang, Ahmed H. El‐Hashash, Xiao Chen, Hongwei Ouyang

Advanced Science· Volume 7· Issue 23

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Source abstract

Abstract

In article number 2000938, Zi Yin, Junxin Lin, and co‐workers identify a novel musculoskeletal stem cell population by single‐cell transcriptional profiling with lineage tracing data during limb development. The differentiation potential and trajectory of musculoskeletal stem cells showed they could contribute to soft and hard connective tissues, as well as muscular tissue. These results suggest an indispensable role of limb Scx+ musculoskeletal stem cell population in musculoskeletal system morphogenesis. [Image: see text]

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OpenAlex topics: Biomedical and Engineering Education · Biomedical Ethics and Regulation · Bone fractures and treatments

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