Protein Corona: Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating (Adv. Sci. 10/2019)
Source abstract
Abstract
The development of nanocarriers for drug delivery is challenged by individual blood composition fluctuations. In article number 1802199, Svenja Morsbach and co-workers report the accumulation of immunoglobulins in the protein corona of nanocarriers in IgG-enriched blood plasma resulting in increased cell uptake. This could be prevented by pre-coating the nanocarriers with the “stealth” protein clusterin. Cover design by Stefan Schuhmacher.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Clusterin in disease pathology · Blood properties and coagulation
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Affiliations
Max Planck Institute for Polymer Research Ackermannweg 10 55128 Mainz Germany
Department of Dermatology University Medical Center of the Johannes Gutenberg‐University Mainz Langenbeckstraße 1 55131 Mainz Germany
References
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