journal article·2019-01Open access

High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019)

Zhe A. Cheng, Andres Alba‐Perez, Cristina Gonzalez‐Garcia, Hannah Donnelly, Virginia Llopis‐Hernandez, Vineetha Jayawarna, Peter Childs, David W. Shields, Marco Cantini, Laura Ruiz‐Cantu, Andrew Reid, James F. C. Windmill, Elena S. Addison, Sandra Corr, William G. Marshall, Matthew J. Dalby, Manuel Salmeron‐Sanchez

Advanced Science· Volume 6· Issue 2

Abstract

In article number 1800361, Matthew J. Dalby, Manuel Salmeron-Sanchez, and co-workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP-2 with high efficiency. This is used as a novel regenerative approach to heal critical-sized bone defects. Simultaneous integrin and growth factor receptor synergistic signaling drives stem cell differentiation leading to bone regeneration in the first veterinary patient. Image credit: Aleixandre Rodrigo-Navarro and Sara Trujillo-Muñoz.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Periodontal Regeneration and Treatments

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Affiliations

Centre for the Cellular Microenvironment University of Glasgow G12 8LT Glasgow UK

Centre for Additive Manufacturing University of Nottingham Nottingham UK

Centre for Ultrasonic Engineering Department of Electronic and Electrical Engineering University of Strathclyde Glasgow UK

Small Animal Hospital University of Glasgow Glasgow UK

References

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