BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
Source abstract
Abstract
Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number 1903616, Qiang Chen, Chu-Xia Deng, and co-workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy to eliminate damaged mitochondria and reactive oxygen species through regulating mitochondrial dynamics, thereby blocking inflammasome activation to prevent mammary tumor metastasis.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Sirtuins and Resveratrol in Medicine · Cancer-related molecular mechanisms research · Ferroptosis and cancer prognosis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Cancer Center Faculty of Health Sciences University of Macau Macau Macau, SAR China
Center for Precision Medicine Research and Training University of Macau Macau Macau, SAR China
Zhuhai UM Science and Technology Research Institute Zhuhai 519031 China
Department of Surgery Kyushu University Beppu Hospital Beppu‐shi Oita 874‐0838 Japan
References
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