Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)

In article number 1700578, Jianzhong Xu, Shiwu Dong, and co-workers report the development of a graphene-based miRNA transfection system that uses a polyethylenimine (PEI) functionalized graphene oxide complex loaded with miR-7b plasmid. The system efficiently delivers the miR-7b plasmid into bone marrow macrophases and reduces the expression of target protein dendritic cell-specific transmembrane protein, specifically targeting cell–cell fusion to block the formation of mature osteoclasts while preserving beneficial preosteoclasts.