journal article·2025-09Open access

An Osteoconductive Janus Hydrogel with Full Barrier Protection and Adaptable Degradation Properties for Superior Bone Regeneration

Yanhui Lu, Jia Song, Yongle Lv, Boon Chin Heng, Mingming Xu, Ying He, Youde Liang, Lu‐Ning Wang, Tingting Wu, Ting Song, Tingjun Li, Qiaomei Ren, Lei Wang, Xuliang Deng, Xuehui Zhang

Advanced Science· Volume 12· Issue 34

Abstract

Abstract Implant materials for bone regeneration necessitate a barrier function to block bacterial adhesion and fibroblast infiltration, while maintaining a delicate equilibrium between material degradation and osteogenesis. Here, a spatiotemporally and hierarchically‐guided bone regeneration hydrogel with a Janus structure is engineered through a sequential photocuring protocol, which features full barrier protection by the outer dense phase and superior osteoconductivity within the inner loose phase. The Janus hydrogel exhibits stable spatiotemporal layering, adaptable degradation, asymmetrical combination of network structures, and mechanical strength. The dense phase, with space maintenance capacity, completely covers the defective area, continuously blocking fibroblast infiltration, and preventing bacterial adhesion. In addition, the loose phase is shape‐adapted to the defective cavity, allowing osteoblast‐associated cells to migrate and create a favorable osteogenic microenvironment. In situ implantation of this Janus hydrogel effectively promoted osteogenesis, angiogenesis, and neurogenesis in both mouse calvarial and rat periodontal bone defect models. Furthermore, the osteogenic efficiency achieved by the Janus hydrogel implanted in mouse calvarial defects and rat periodontal defects is increased by 42% and 13.7%, respectively, as compared with previous studies. These findings thus demonstrated the synergy of protective barrier function, osteoconductive properties, and adaptive degradation within a single scaffold, which is conducive to bone regeneration.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Dental Materials & Dental Medical Devices Testing Center Peking University School and Hospital of Stomatology Beijing 100081 P. R. China

Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. China

National Center for Stomatology National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental Materials Beijing Laboratory of Biomedical Materials & Beijing Key Laboratory of Digital Stomatology NHC Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology Beijing 100081 P. R. China

Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 P. R. China

The department of stomatology center The People's Hospital of Baoan Shenzhen 518100 P. R. China

Oral Translational Medicine Research Center Joint Training base for Shanxi Provincial Key Laboratory in Oral and Maxillofacial Repair Reconstruction and Regeneration The First People's Hospital of Jinzhong Jinzhong Shanxi Province 030600 P. R. China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China

References (52)

Show source-provided references
1. 10.1038/s41563-020-00844-w10.1038/s41563-020-00844-w ↗
2. 10.1016/j.jot.2022.01.00210.1016/j.jot.2022.01.002 ↗
3. Xie L. · Innovation · 2021 · 2
4. 10.1002/adhm.20200070710.1002/adhm.202000707 ↗
5. Zhang W. · Bioact. Mater. · 2020 · 6 · 975
6. 10.1039/b713009k10.1039/b713009k ↗
7. 10.1016/j.addr.2021.02.00210.1016/j.addr.2021.02.002 ↗
8. 10.1016/j.addr.2016.07.00410.1016/j.addr.2016.07.004 ↗
9. 10.1002/adma.20190571910.1002/adma.201905719 ↗
10. 10.1016/j.bioactmat.2022.02.02410.1016/j.bioactmat.2022.02.024 ↗
11. 10.1002/adma.20150537510.1002/adma.201505375 ↗
12. Zheng A. · Bioact Mater. · 2022 · 21 · 403
13. 10.1002/adfm.20190620510.1002/adfm.201906205 ↗
14. 10.1002/advs.20240647910.1002/advs.202406479 ↗
15. 10.1186/s40168-024-01768-210.1186/s40168-024-01768-2 ↗
16. 10.3390/ma609384010.3390/ma6093840 ↗
17. 10.3389/fendo.2021.75984310.3389/fendo.2021.759843 ↗
18. 10.1515/cmble-2015-001110.1515/cmble-2015-0011 ↗
19. 10.1016/S1350-9462(02)00009-510.1016/S1350-9462(02)00009-5 ↗
20. 10.7150/thno.7454810.7150/thno.74548 ↗
21. 10.1016/j.addr.2012.09.04310.1016/j.addr.2012.09.043 ↗
22. 10.1016/j.actbio.2021.02.01810.1016/j.actbio.2021.02.018 ↗
23. 10.1016/j.msec.2016.08.07010.1016/j.msec.2016.08.070 ↗
24. 10.1039/D0TB02822C10.1039/D0TB02822C ↗
25. 10.1002/adma.20231026010.1002/adma.202310260 ↗
26. 10.1016/j.ijbiomac.2023.12562410.1016/j.ijbiomac.2023.125624 ↗
27. 10.1016/j.bioactmat.2023.02.00810.1016/j.bioactmat.2023.02.008 ↗
28. 10.1016/j.bioactmat.2024.08.03510.1016/j.bioactmat.2024.08.035 ↗
29. 10.1016/j.bioadv.2022.21302710.1016/j.bioadv.2022.213027 ↗
30. 10.1007/s11538-014-0055-310.1007/s11538-014-0055-3 ↗
31. 10.1021/acsami.2c1866410.1021/acsami.2c18664 ↗
32. 10.1002/adhm.20210182010.1002/adhm.202101820 ↗
33. 10.1016/j.actbio.2013.08.04410.1016/j.actbio.2013.08.044 ↗
34. 10.1016/j.actbio.2019.09.01810.1016/j.actbio.2019.09.018 ↗
35. 10.1016/j.ijbiomac.2017.01.10710.1016/j.ijbiomac.2017.01.107 ↗
36. 10.1016/j.actbio.2020.02.02410.1016/j.actbio.2020.02.024 ↗
37. 10.1016/j.msec.2020.11117510.1016/j.msec.2020.111175 ↗
38. 10.1007/s42765-023-00297-110.1007/s42765-023-00297-1 ↗
39. Thevenot P. · Proc IEEE Conf Nanotechnol. · 2008 · 2008 · 646
40. 10.1016/j.addr.2019.09.00310.1016/j.addr.2019.09.003 ↗
41. 10.1016/j.chom.2019.06.00210.1016/j.chom.2019.06.002 ↗
42. 10.1016/j.msec.2021.11229810.1016/j.msec.2021.112298 ↗
43. 10.1902/jop.1995.66.6.52210.1902/jop.1995.66.6.522 ↗
44. 10.1016/j.dental.2021.12.02610.1016/j.dental.2021.12.026 ↗
45. Zhang M. · Bioact Mater. · 2023 · 31 · 368
46. 10.1016/j.actbio.2021.03.06810.1016/j.actbio.2021.03.068 ↗
47. 10.1021/acsami.2c1251310.1021/acsami.2c12513 ↗
48. 10.2147/IJN.S24453310.2147/IJN.S244533 ↗
49. 10.1902/jop.2001.72.11.161610.1902/jop.2001.72.11.1616 ↗
50. 10.1038/s41467-023-43476-910.1038/s41467-023-43476-9 ↗
51. 10.1038/s41586-020-2050-110.1038/s41586-020-2050-1 ↗
52. 10.1016/j.molcel.2021.08.02710.1016/j.molcel.2021.08.027 ↗