Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer (Adv. Sci. 18/2025)

Guangyu Zhang; Xin Zhang; Wenting Pan; Xizhao Chen; Lingfei Wan; Chunjie Liu; Yuting Yong; Yue Zhao; Shuli Sang; Lihua Zhang; Sheng Yao; Yushu Guo; Mingmei Wang; Xinhui Wang; Guangdun Peng; Xinlong Yan; Yanchun Wang; Min Zhang

doi:10.1002/advs.202570136

journal article·2025-05Open access

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer (Adv. Sci. 18/2025)

Guangyu Zhang, Xin Zhang, Wenting Pan, Xizhao Chen, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang

Advanced Science· Volume 12· Issue 18

Publisher page Open full text

Source abstract

Abstract

Gastric Cancer Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang, and co-workers meticulously conducted an in-depth and comprehensive exploration of the single-cell and spatial transcriptomic landscape of gastric cancer initiation and progression. They prominently highlighted the crucial role of inflammatory cancer-associated fibroblast in regulation of stemness, drug resistance, and self-renewal of cancer stem cells (CSCs) during gastric cancer progression. More details can be found in article number 2413019.

Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cancer Cells and Metastasis · Cancer Genomics and Diagnostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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