Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis (Adv. Sci. 18/2025)

Echinococcus Multilocularis In article number 2405914, Wan-Zhong Jia, Junhua Li, Hong-Bin Yan, and co-workers decipher the shift in host (Nezha) immune response strategies from “active killing” to “negative segregation” during Echinococcus multilocularis hepatic infection. During the early infection stage, neutrophils (fire-tipped spear) and macrophages (wind fire wheels) collaborate to eliminate protoscoleces (goblins). In the middle and late stages, macrophages and fibroblasts (red armillary sash) cooperate to physically isolate the continuously expanding microcyst (monster).