MLLT3 Regulates Melanoma Stemness and Progression by Inhibiting HMGB1 Nuclear Entry and MAGEA1 M⁵C Modification (Adv. Sci. 10/2025)

MLLT3 Regulates Melanoma Stemness MLLT3 is a transcription factor that regulates the stemness and progression of melanoma. In the cytoplasm, MLLT3 tightly binds to YBX1, inhibiting the m5C reading of MAGEA1, thereby suppressing the mRNA stability of MAGEA1. This directly leads to the transcriptional activation of P53, which in turn suppresses the stemness, proliferation, and metastasis of melanoma cells. More details can be found in article number 2408529 by Yaling Li, Bo Yu, Bing Song, and co-workers.