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journal article·2024-11Open access

Nanoarchitecture‐Integrated Hydrogel Boosts Angiogenesis–Osteogenesis–Neurogenesis Tripling for Infected Bone Fracture Healing (Adv. Sci. 43/2024)

Kangkang Zha, Weixian Hu, Yuan Xiong, Shengming Zhang, Meijun Tan, Pengzhen Bu, Yanzhi Zhao, Wenqian Zhang, Ze Lin, Yiqiang Hu, Mohammad‐Ali Shahbazi, Qian Feng, Guohui Liu, Bobin Mi

Advanced Science· Volume 11· Issue 43
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Source abstract

Abstract

Infected Fracture Healing In article number 2406439, Qian Feng, Guohui Liu, Bobin Mi, and co-workers develop a pH-responsive nanoarchitecture-integrated hydrogel to treat bacteria-infected fracture through controlled release of humic acids, Zn2+, and Ga3+. This hydrogel promotes angiogenesis, osteogenesis, and neurogenesis. The enhanced neurogenesis further promotes angiogenesis and osteogenesis, forming a mutually supportive angiogenesis-osteogenesis-neurogenesis cycle at the fracture site, proving a promising whole-course-repair strategy for infected fracture healing.
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Research context

PolymersNanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Bone Tissue Engineering Materials

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