Cellular Uptake of Phase‐Separating Peptide Coacervates (Adv. Sci. 42/2024)

Peptide Coacervates for Intracellular Therapeutic Delivery Peptide coacervate microdroplets (CMs) are promising vectors to deliver a broad range of macromolecular therapeutics inside cells, but the mechanism by which CMs enter cells has remained unknown to date. In article number 2402652, Ali Miserez and co-workers demonstrate that CMs enter the cell through a mechanism reminiscent of macropinocytosis and phagocytosis. The cover image is a scanning electron microscope (SEM) image of CMs captured by filipodia protrusions of HeLa cells, which is the first step in the internalization process of CMs within cells. The image was false-colored for visualization purposes.