A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm (Adv. Sci. 29/2024)

Novel Drug Candidate for Sepsis Sepsis currently has no specific clinical treatment. The main cause of multi-organ failure and death in sepsis is increased vascular permeability due to endothelial damage. Hongzhen Jin, Wei Zhao, Fan Yu, and co-workers have developed a drug targeting Heparanase through screening. The drug significantly protects the vascular endothelial glycocalyx and improves survival rates in sepsis mouse models from 0 to 80%, making it a promising candidate for sepsis. More details can be found in article number 2403337.