journal article·2024-07Open access

Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons (Adv. Sci. 27/2024)

Zixuan Lu, Chiara Barberio, Ana Fernandez‐Villegas, Aimee Withers, Alexandra Wheeler, Konstantinos Kallitsis, Eleonora Martinelli, Achilleas Savva, Becky M. Hess, Anna‐Maria Pappa, Gabriele S. Kaminski Schierle, Róisín M. Owens

Advanced Science· Volume 11· Issue 27

Abstract

Neuronal-Membrane-on-Chip The cover highlights a novel platform of interfacing cell membranes derived from primary neurons with organic microelectrode arrays for monitoring ion channel activities at natively-expressed levels. In article number 2304301, Róisín M. Owens and colleagues showcase the ease of testing, rapidity, ultra-sensitivity, and high-throughput capabilities. This work introduces a new class of neuroscience tools promising to unveil insights into drug and ion-channels interactions. Art by the team of Inmywork Studio.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrochemical Analysis and Applications · Neuroscience and Neural Engineering · Lipid Membrane Structure and Behavior

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