Cutaneous Calcium/Calmodulin‐Dependent Protein Kinase II‐γ–Positive Sympathetic Nerves Secreting Norepinephrine Dictate Psoriasis (Adv. Sci. 23/2024)

Sympathetic Nerves In article number 2306772, Qi Zhen, Liangdan Sun, and co-workers elaborate the mechanisms of sympathetic-nervous-system regulation of γδT-cell interleukin-17 secretion and skin immune responses which unveil novel insights into cutaneous CaMK2γ+ sympathetic nerves functioned in the pathogenesis of psoriasis. CaMK2γ is activated in imiquimod- or stress-activated sympathetic nerves and increases the interleukin-17 production of dermal γδT cells through the norepinephrine–γδT–adrenoceptor β1–NF-κB and –p38 axes in the skin, resulting in excessive psoriatic inflammation.