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journal article·2022-07Open access

Human Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing (Adv. Sci. 21/2022)

Zhong Li, Zixuan Lin, Silvia Liu, Haruyo Yagi, Xiurui Zhang, Lauren Yocum, Monica Romero‐Lopez, Claire Rhee, Meagan J. Makarcyzk, Ilhan Yu, Eileen N. Li, Madalyn R. Fritch, Qi Gao, Kek Boon Goh, Benjamen O'Donnell, Tingjun Hao, Peter G. Alexander, Bhushan Mahadik, John P. Fisher, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Hang Lin

Advanced Science· Volume 9· Issue 21
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Source abstract

Abstract

Human Mesenchymal Stem Cell‐Derived Miniature Joint System In article number 2105909 by Rocky S. Tuan, Hang Lin, and co‐workers, a miniature synovial joint‐mimicking system (miniJoint) is established in a microfluidics‐enabled bioreactor, in which human mesenchymal stem cell‐derived bone‐cartilage complex, synovial‐like fibrous tissue, and adipose tissue are integrated and show active crosstalk. The data demonstrate the potential of miniJoint as a new model for the study of joint pathology and the development of novel therapeutic interventions. [Image: see text]
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Research context

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Mesenchymal stem cell research · 3D Printing in Biomedical Research

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