journal article·2021-07Open access

Drug Delivery: Delivering Antisense Oligonucleotides across the Blood‐Brain Barrier by Tumor Cell‐Derived Small Apoptotic Bodies (Adv. Sci. 13/2021)

Yulian Wang, Jiayun Pang, Qingyun Wang, Luocheng Yan, Lintao Wang, Zhen Xing, Chunming Wang, Junfeng Zhang, Lei Dong

Advanced Science· Volume 8· Issue 13

Abstract

Brain, guarded by the most rigorous barrier — blood‐brain barrier (BBB), is the most critical and sophisticated control center in the body. The dead bodies from melanoma cells, small apoptotic bodies with membrane embedded CD44v6 molecules could pass through BBB and deliver drugs for the cure of Parkinson's disease. The apoptotic body might be a new type of carrier for efficient in vivo drug delivery. More details can be found in article number 2004929 by Chunming Wang, Junfeng Zhang, Lei Dong, and co‐workers. [Image: see text]
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Research context

OpenAlex topics: RNA Interference and Gene Delivery · Cancer Research and Treatments · MicroRNA in disease regulation

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