DataVXAdvanced SciencePaper
journal article·2019-04Open access

Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019)

Jing Xu, Hongsheng Wang, Yi Hu, Yu Shrike Zhang, Longping Wen, Fei Yin, Zhuoying Wang, Yingchao Zhang, Suoyuan Li, Yanyan Miao, Binhui Lin, Dongqing Zuo, Gangyang Wang, Min Mao, Tao Zhang, Jianxun Ding, Yingqi Hua, Zhengdong Cai

Advanced Science· Volume 6· Issue 8
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Source abstract

Abstract

In article number 1801233, Jianxun Ding, Yingqi Hua, Zhengdong Cai, and co-workers report a combination strategy for improving the efficacy of fullerene C60 nanocrystals in anti-osteosarcoma therapy. Inhibition of CaMKIIα activity by KN-93 promotes excessive autophagosome accumulation and autophagic degradation blockage through lysosomal dysfunction induction and further upregulates the anti-osteosarcoma effect of fullerene C60 nanocrystals.
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Research context

Nanomaterials

OpenAlex topics: Fullerene Chemistry and Applications · Graphene and Nanomaterials Applications · ATP Synthase and ATPases Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedics Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai Bone Tumor Institution 100 Haining Street Shanghai 200080 P. R. China

Shanghai Bone Tumor Institution 100 Haining Street Shanghai 200080 P. R. China

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of China 96 Jinzhai Street Hefei 230026 P. R. China

Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School 65 Landsdowne Street Cambridge MA 02139 USA

School of Medicine South China University of Technology Nanobio Laboratory Institutes for Life Sciences South China University of Technology 381 Wushan Street Guangzhou 510006 P. R. China

Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory of Biocontrol School of Life Sciences Sun Yat‐sen University 135 West Xingang Street Guangzhou 510275 P. R. China

Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences 5625 Renmin Street Changchun 130022 P. R. China

References

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