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journal article·2025-05Open access

Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck Cancer

Lizhuo Zhang, Qingqing Feng, Chuanming Zheng, Yuanqiang Li, Xinyang Ge, Tiefeng Jin, Gaofeng Hu, Zhuo Tan, Jiafeng Wang, Jiajie Xu, Liehao Jiang, Dan Wang, Zhangguo Ying, Xiao Zhao, Keman Cheng, Qinglin Li, Minghua Ge

Advanced Science· Volume 12· Issue 18
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Source abstract

Abstract

Abstract A significant challenge in cancer therapy is the identification of suitable targets that are specifically and uniformly expressed across heterogeneous tumors. The efficacy of pre‐existing antiviral immunity in tumor treatment is limited by the absence of corresponding targets. This study develops a novel platform of antigen‐targeted inserted nanomicelles, preS1 (an antigen of hepatitis B virus)‐pHLIP nanomicelles, in which tumor‐targeting nanomicelles release antigens that label tumor tissue for pre‐existing immunity‐mediated lysis in situ. In animal models of head and neck cancers, including head and neck squamous cell carcinoma and anaplastic thyroid cancer, preS1‐pHLIP nanomicelles effectively inhibited tumor growth, recurrence, and metastasis in animals pre‐immunized with preS1. This therapeutic effect is associated with an increase in the proportion of preS1‐specific B cells and activated tumor‐specific T cells within the tumor microenvironment. Overall, this work has engineered a nanomicelle that can disguise tumor cells as viruses and achieve tumor killing through the pre‐existing antiviral immune response. This strategy presents a novel approach for treating tumors with ambiguous therapeutic target profiles.
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Research context

Nanomaterials

OpenAlex topics: Immunotherapy and Immune Responses · RNA Interference and Gene Delivery · Virus-based gene therapy research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Otolaryngology & Head and Neck Center Cancer Center Department of Head and Neck Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou 310014 China

Zhejiang Provincial Clinical Research Center for Head & Neck Cancer Hangzhou 310014 China

Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer Hangzhou 310014 China

Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou 310006 China

Zhejiang Cancer Hospital Hangzhou 310005 China

Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193 China

Cancer Centre Faculty of Health Sciences University of Macau Macau SAR 999078 China

Department of Thyroid and Breast Surgery Zhejiang Provincial People's Hospital Bijie Hospital Bijie 551700 China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · National Key Research and Development Program of China · Natural Science Foundation of Beijing Municipality

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