Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38‐Targeted Lipid Nanoparticles (Adv. Sci. 21/2023)

Dana Tarab‐Ravski; Inbal Hazan‐Halevy; Meir Goldsmith; Lior Stotsky‐Oterin; Dor Breier; Gonna Somu Naidu; Anjaiah Aitha; Yael Diesendruck; Brandon D. Ng; Hagit Barsheshet; Tamar Berger; Iuliana Vaxman; Pia Raanani; Dan Peer

doi:10.1002/advs.202370141

journal article·2023-07Open access

Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38‐Targeted Lipid Nanoparticles (Adv. Sci. 21/2023)

Dana Tarab‐Ravski, Inbal Hazan‐Halevy, Meir Goldsmith, Lior Stotsky‐Oterin, Dor Breier, Gonna Somu Naidu, Anjaiah Aitha, Yael Diesendruck, Brandon D. Ng, Hagit Barsheshet, Tamar Berger, Iuliana Vaxman, Pia Raanani, Dan Peer

Advanced Science· Volume 10· Issue 21

Publisher page Open full text

Source abstract

Abstract

Targeted LNPs Delivery to the Bone Marrow In article number 2301377, Dana Tarab-Ravski, Dan Peer, and co-workers develop targeted lipid nanoparticles to efficiently deliver therapeutic RNA to multiple myeloma cells in the bone marrow. In a novel xenograft multiple myeloma (MM) mouse model, this delivery system demonstrates its ability to specifically target MM cells and produce a positive clinical outcome in mice engrafted with MM.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Calcium signaling and nucleotide metabolism · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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