YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes (Adv. Sci. 19/2024)

YY1 Lactylation Activated microglia in the retina are essential for the development of autoimmune uveitis. The center of this image presents YY1 lactylation (lactylation at 183 lysine of YY1), which stands between the normal microglia (resting state with ramified shape) and the activated microglia (activated state with ameboid shape). The cover shows the main findings of the research that YY1 lactylation enhances microglial functions in autoimmune uveitis. More details can be found in article number 2308031 by Peizeng Yang, Shengping Hou, and co-workers.