DataVXAdvanced SciencePaper
journal article·2019-04Open access

Cancer Radiotherapy: Enhanced Radiosensitization by Gold Nanoparticles with Acid‐Triggered Aggregation in Cancer Radiotherapy (Adv. Sci. 8/2019)

Yumin Zhang, Fan Huang, Chunhua Ren, Jinjian Liu, Lijun Yang, Shizhu Chen, Jinglin Chang, Cuihong Yang, Weiwei Wang, Chuangnian Zhang, Qiang Liu, Xing‐Jie Liang, Jianfeng Liu

Advanced Science· Volume 6· Issue 8
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Source abstract

Abstract

In article number 1801806, Xing-Jie Liang, Jianfeng Liu, and co-workers develop a gold nanoparticles (GNPs) system with acid-triggered aggregation as a radiosensitizer. With a sensitizer enhancement ratio (SER) value of 1.730 (vs. single GNPs of 1.16), this GNPs system improves sensitivity of MCF-7 cells and MCF-7 tumor xenograft to ionizing radiation. This work provides a strategy for fabricating radiosensitizer by in situ acid-triggered nano-aggregates formation.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 P. R. China

CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Chinese Academy of Sciences and National Center for Nanoscience and Technology of China Beijing 100190 China

Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Science and Peking Union Medical College Tianjin 300192 P. R. China

University of Chinese Academy of Sciences Beijing 100049 P. R. China

References

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