Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies
Source abstract
Abstract
ABSTRACT Pathological scarring after skin wound healing poses a substantial clinical difficulty, essentially representing a fibrotic outcome of dysregulated tissue repair. This review provides a comprehensive analysis of the physiological processes of wound healing and key factors in scar formation, focusing on the unique mechanisms of scarless regeneration models such as early‐stage fetuses and spiny mouse ( Acomys cahirinus ). These models rely heavily on the immune microenvironment's regulation, the dynamic remodeling of the extracellular matrix (ECM), and precise cell behavior regulation to achieve perfect regeneration. Building upon this foundation, this review delves into emerging scar prevention methods from the perspective of tissue engineering materials. These encompass multi‐dimensional interventions, including the construction of biomimetic microenvironments, regulation of key cell fates, sequential multi‐target intervention in pathological processes, and the integration of smart materials with advanced manufacturing technologies. Through interdisciplinary integration and innovation, shifting scar prevention and treatment strategies from passive anti‐fibrosis to proactive promoting regeneration, guiding wounds toward true structural and functional regeneration, emerges as a promising path to overcome current limitations in scar management.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Periodontal Regeneration and Treatments · Corneal Surgery and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Histology and Embryology NMPA Key Laboratory for Safety Evaluation of Cosmetics GDMPA Key Laboratory of Key Technologies for Cosmetics Safety and Efficacy Evaluation School of Basic Medical Sciences Southern Medical University Guangzhou P. R. China
Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou P. R. China
Department of Sports Medicine Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third School of Clinical Medicine, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases The Third Affiliated Hospital of Southern Medical University Guangzhou P. R. China
Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province P. R. China
School of Materials Science and Engineering Changchun University of Science and Technology Changchun P. R. China
School of Biomedical Engineering, Affiliated Cancer Hospital & Institute Guangzhou Medical University Guangzhou P. R. China
Funding
National Natural Science Foundation of China · Basic and Applied Basic Research Foundation of Guangdong Province
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