IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody
Abstract
Research context
OpenAlex topics: SARS-CoV-2 and COVID-19 Research · Monoclonal and Polyclonal Antibodies Research · Advanced Biosensing Techniques and Applications
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Affiliations
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China
Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
Research Unit of Nanoscience and Technology Chinese Academy of Medical Sciences Beijing 100730 China
Comprehensive AIDS Research Center Pandemic Research Alliance Unit Center for Infection Biology School of Basic Medical Sciences Tsinghua University Beijing 100084 China
State Key Laboratory of Chemical Engineering and Low‐carbon Technology Department of Chemical Engineering and Low‐carbon Technology Tsinghua University Beijing 100084 China
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences Beijing 100190 China
College of Ecology Lanzhou University Lanzhou 730000 China
University of Chinese Academy of Sciences Beijing 100049 China
The Salk Institute of Biological Sciences La Jolla CA 92037 USA
The Ministry of Education Key Laboratory of Protein Science Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University Beijing 100084 China
CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China
MOE Engineering Research Center of Advanced Rare Earth Materials Department of Chemistry Tsinghua University Beijing 100084 China
Shanghai Institute of Infectious Disease and Biosecurity Shanghai Medical College Fudan University Shanghai 200032 China
Centre for Virology Vaccinology and Therapeutics Department of Microbiology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR 999077 China
The technology center for protein science Tsinghua University Beijing 100084 China
Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Hum Kowloon 999077 Hong Kong
PolyU Shenzhen Research Institute Shenzhen 518057 China
Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences Institute Zhejiang University Hangzhou 310058 China
Institute of Bio‐Architecture and Bio‐Interactions Shenzhen Medical Academy of Research and Translation Shenzhen Guangdong 518107 China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience Beijing 100190 China
Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Beijing 100142 China
Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 China
Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory Shenzhen 518132 China
Funding
National Key Research and Development Program of China · Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China