Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Abstract
Research context
OpenAlex topics: Hemoglobinopathies and Related Disorders · Epigenetics and DNA Methylation · Acute Myeloid Leukemia Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University 130 Dong'An Road Shanghai 200032 China
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences No.1 Xiangshan Road Hangzhou 310024 China
Institute of Drug Discovery China‐New Zealand Joint Laboratory on Biomedicine and Health Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences 190 Kaiyuan Avenue Guangzhou 510530 China
The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences Nanjing University Nanjing 210023 China
GMU‐GIBH Joint School of Life Sciences, The Guangdong‐Hong Kong‐Macao Joint Laboratory for Cell Fate Regulation and Diseases Guangzhou Medical University Guangzhou 511436 China
Department of Hepatobiliary Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Institutes of Biomedical Sciences, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism Zhongshan Hospital Fudan University Shanghai 200032 China
Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Department of Medical Genetics, School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong 510515 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China
Funding
Guangzhou Municipal Science and Technology Bureau · Basic and Applied Basic Research Foundation of Guangdong Province · National Key Research and Development Program of China · National Natural Science Foundation of China