Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells (Adv. Sci. 42/2025)

Boosting Cryopreserved Natural Killer Cytotoxicity In their Research Article (DOI: 10.1002/advs.202505731), Bin Qu and co-workers present a strategy to enhance the cytotoxic activity of natural killer (NK) cells using IL-2-presenting synthetic cells. This approach significantly boosts the tumor-killing function of both freshly isolated and cryopreserved NK cells-including CAR-engineered NK cells. Notably, synthetic cells displaying IL-15 produce similar effects. This innovative platform provides a powerful and clinically relevant method to advance off-the-shelf NK cell-based immunotherapies.