journal article·2026-01Open access

Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large‐Scale Coverage Neural Recorder

Hongru Liu, Xinyuan Cao, Jiyong Li, Lingyi Zheng, Jingwei Li, Qianbing Li, Min Xie, Huimin Li, Xiaolong Wang, Yuyu Wu, Xiangyu Zhang, Yizheng Wang, Xize Gao, Tiancheng Sheng, Nianzhen Du, Chengao Xu, Kai Zhou, Jing Xu, Changxiang Yan, Lianqing Liu, Lixia Gao, Xinjian Li, Mingjun Zhang

Advanced Science· Volume 13· Issue 2

Abstract

Abstract Deciphering neural mechanisms underlying dynamic natural behaviors of freely moving species requires long‐term recordings of large‐scale brain activities. However, most conventional neural recorders are limited by their weights and measures, electrode coverage, and signal throughput, hindering the dissection of underlying neural mechanisms. This study reports real‐time large‐scale recordings and deciphering of brain activities from frontal and temporal cortices of freely moving marmoset across various natural behavioral repertoire using a miniaturized wireless neural recorder comprising a custom‐designed 120‐channel flexible µECoG array. Behavior‐specific highly resolved spatiotemporal neural dynamics are observed, including alpha‐band activations during drinking, anticipatory responses before vocalization, and transient high‐gamma increase during vigilance to human intruders. Three phases of drinking behavior are identified using multi‐area neural features captured by the recorder with an accuracy exceeding 87%. After over 16 months (March 13, 2024‐August 1, 2025, remaining actively recording) of recordings, the neural signals acquired using the recorder maintain high fidelity and low attenuation during both the resting and drinking states, enabling potential long‐term dissection of the neural mechanisms of natural behaviors in freely moving marmosets.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Animal Vocal Communication and Behavior · Neural dynamics and brain function · Zebrafish Biomedical Research Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering Tsinghua University Beijing 100084 China

Department of Neurology of the Second Affiliated Hospital and Interdisciplinary Institute of Neuroscience and Technology Zhejiang University School of Medicine Hangzhou 310029 China

Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou 310027 China

Department of Mechanical Engineering Tsinghua University Beijing 100084 China

Department of Neurosurgery, Sanbo Brain Hospital Capital Medical University Beijing 100093 China

State Key Laboratory of Robotics and Intelligent Systems, Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110016 China

Nanhu Brain‐computer Interface Institute Hangzhou 311100 China

NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain‐machine Integration, School of Brain Science and Brain Medicine Zhejiang University Hangzhou 310058 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China

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