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journal article·2025-10Open access

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng

Advanced Science· Volume 12· Issue 40
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Source abstract

Abstract

Abstract Cortical traveling waves coordinate communication among distributed neural ensembles to modulate brain function and dysfunction through distinct spatiotemporal propagation patterns. However, the brain‐wide propagation dynamics of traveling waves from different origins and their roles in regulating behavior remain unclear. Using optogenetics alongside whole‐brain fMRI in mice, it is demonstrated that optogenetic activation of the medial prefrontal cortex and primary somatosensory area induces cortical spreading depression (CSD)‐like traveling waves. These waves propagate beyond the ipsilateral cortex to the contralateral cortex and midbrain, reaching subcortical structures along cortico‐amygdala‐striatal pathways, ultimately terminating in the striatum ≈4 min after induction. The propagation directions in the cortex, speed, duration, and region involvement vary with wave origins. Furthermore, these CSD‐like traveling waves induce anxiety‐like behaviors and increase dendritic spine density. The findings elucidate the complete process from induction to termination of traveling waves across the whole brain and reveal their previously undiscovered role in driving anxiety.
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Research context

OpenAlex topics: Circadian rhythm and melatonin · Functional Brain Connectivity Studies · Photoreceptor and optogenetics research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Mental Health of the Ministry of Education Guangdong‐Hong Kong‐Macao Greater Bay Area Center for Brain Science and Brain‐Inspired Intelligence Guangdong‐Hong Kong Joint Laboratory for Psychiatric Disorders Guangdong Province Key Laboratory of Psychiatric Disorders Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases Department of Neurobiology School of Basic Medical Sciences Southern Medical University Guangzhou 510515...

Department of Radiology The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde) Foshan 528300 China

Guangxi Key Laboratory of Brain and Cognitive Neuroscience Faculty of Basic Medical Sciences Guilin Medical University Guilin Guangxi 541199 China

Department of Neurosurgery Stanford University School of Medicine Stanford CA 94304 USA

School of Biomedical Engineering Guangdong Provincial Key Laboratory of Medical Image Processing Southern Medical University Guangzhou 510515 China

Microbiome Medicine Center Department of Laboratory Medicine Zhujiang Hospital Southern Medical University Guangzhou Guangdong 510515 China

Institute of Neuroscience CAS Key Laboratory of Primate Neurobiology Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China

Laboratory of Biomedical Imaging and Signal Processing Department of Electrical and Electronic Engineering The University of Hong Kong Pokfulam Hong Kong SAR China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · China Postdoctoral Science Foundation · Basic and Applied Basic Research Foundation of Guangdong Province

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