M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1^hi Neutrophils to Enhance Inflamed Bone Regeneration (Adv. Sci. 28/2025)

Inflamed Bone Regeneration In article number 2416159, Yufei Yao, Yijia Yin, Xianglong Han, and co-workers present a newly discovered Anxa1hi neutrophil subpopulation (Earth), influenced by M2-EVs (Space Station), which shifts its differentiation from an inflammatory state (Mars). The cover art symbolizes the role of M2-EVs in neutrophil differentiation and the reparative effects of Anxa1hi neutrophils, with newly bone and blood vessel formation on Earth (also reflecting the state of homeostasis).