Advances in Medical Devices for Augmented Acupuncture Therapy
Source abstract
Abstract
Abstract Acupuncture, as a traditional medicine applied worldwide, is considered an effective treatment for numerous chronic diseases. Many researches have explored the biological mechanisms of acupuncture, including the skin‐neuro‐immune axis and inflammation‐immune modulation. However, traditional acupuncture faces several limitations, such as its complex operation, the wide variety of acupoint combinations, long treatment durations, and susceptibility to individual differences between the practitioner and the patient. These challenges highlight the urgent need for intelligent medical devices that enable more precise and efficient modern acupuncture treatment. In response to this, this manuscript introduces engineered acupuncture needles (EANs) using techniques such as macroscopic mechanical etching, microscopic surface modification, and biomedical nanotechnology. These modified needles enhance acupuncture treatment by incorporating drug delivery, electrical stimulation, and thermal stimulation technologies. Here we provide an overview of recent advancements in EANs in terms of materials, fabrication methods, engineering technologies, acupoints, as well as disease models. The relevant bottlenecks and future prospects of their development are also discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Acupuncture Treatment Research Studies · Vagus Nerve Stimulation Research · Pain Mechanisms and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems School of Pharmacy Zhejiang University Hangzhou 310058 China
Pharmaceutical Sciences Shandong University Jinan Shandong 250012 China
Jinhua Institute of Zhejiang University Jinhua 321299 China
Department of General Surgery, Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China
Center for General Practice Medicine, Department of Endocrinology Zhejiang Provincial People's Hospital, Affiliated People's Hospital Hangzhou medical college Hangzhou 310014 China
Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province Hangzhou 310014 China
Department of Burns and Wound Care Center Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China
MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China
Institute of Fundamental and Transdisciplinary Research Zhejiang University Hangzhou 310058 China
Funding
National Natural Science Foundation of China
References (84)
Show source-provided references
1. 10.1002/art.4158410.1002/art.41584 ↗
2. 10.1001/jamanetworkopen.2021.4250910.1001/jamanetworkopen.2021.42509 ↗
3. 10.1001/jamaoncol.2019.523310.1001/jamaoncol.2019.5233 ↗
4. 10.1001/jamapsychiatry.2023.565110.1001/jamapsychiatry.2023.5651 ↗
5. 10.3390/vetsci808014910.3390/vetsci8080149 ↗
6. 10.1126/sciadv.aax134210.1126/sciadv.aax1342 ↗
7. 10.4236/eng.2013.510B11210.4236/eng.2013.510B112 ↗
8. 10.1002/advs.20240324510.1002/advs.202403245 ↗
9. 10.1089/acu.2020.148810.1089/acu.2020.1488 ↗
10. 10.1186/s12906-015-0625-410.1186/s12906-015-0625-4 ↗
11. 10.3389/fimmu.2023.124264010.3389/fimmu.2023.1242640 ↗
12. 10.2147/JIR.S34158110.2147/JIR.S341581 ↗
13. 10.1038/s41586-021-04001-410.1038/s41586-021-04001-4 ↗
14. 10.1016/j.conb.2022.10260210.1016/j.conb.2022.102602 ↗
15. Fei Y.‐T. · Br. Med. J. · 2022 · 376
16. 10.1039/D3NH00469D10.1039/D3NH00469D ↗
17. 10.1001/jamanetworkopen.2022.4172010.1001/jamanetworkopen.2022.41720 ↗
18. 10.1136/bmj.m109610.1136/bmj.m1096 ↗
19. 10.1016/S0006-3223(97)00394-610.1016/S0006-3223(97)00394-6 ↗
20. 10.1097/ALN.000000000000010110.1097/ALN.0000000000000101 ↗
21. 10.1136/gut.35.8.102610.1136/gut.35.8.1026 ↗
22. 10.2519/jospt.2016.627010.2519/jospt.2016.6270 ↗
23. 10.1002/adfm.20221273010.1002/adfm.202212730 ↗
24. 10.1016/j.scib.2023.11.03010.1016/j.scib.2023.11.030 ↗
25. Liu Z.‐F. · Orthop. Res. Rev. · 2024 · 16 · 21
26. 10.1155/2012/16839310.1155/2012/168393 ↗
27. 10.1016/j.phymed.2022.15438810.1016/j.phymed.2022.154388 ↗
28. 10.1155/2022/415917210.1155/2022/4159172 ↗
29. 10.1172/JCI4284310.1172/JCI42843 ↗
30. 10.1016/j.neubiorev.2009.10.00310.1016/j.neubiorev.2009.10.003 ↗
31. 10.14336/AD.2022.011510.14336/AD.2022.0115 ↗
32. 10.3389/fmed.2023.97114710.3389/fmed.2023.971147 ↗
33. 10.1016/j.phymed.2022.15438810.1016/j.phymed.2022.154388 ↗
34. 10.1001/jamaoncol.2021.031010.1001/jamaoncol.2021.0310 ↗
35. Onuora S. · Nat. Rev. Rheumatol. · 2021 · 17 · 2
36. 10.1200/JCO.2008.21.769510.1200/JCO.2008.21.7695 ↗
37. 10.1038/s41467-023-36448-610.1038/s41467-023-36448-6 ↗
38. 10.1016/j.mattod.2022.09.01010.1016/j.mattod.2022.09.010 ↗
39. 10.1200/JCO.2022.40.16_suppl.TPS1214510.1200/JCO.2022.40.16_suppl.TPS12145 ↗
40. 10.1002/advs.20240285610.1002/advs.202402856 ↗
41. 10.1111/jcmm.1789110.1111/jcmm.17891 ↗
42. 10.1016/j.jare.2024.06.01810.1016/j.jare.2024.06.018 ↗
43. 10.1038/s41392-019-0061-x10.1038/s41392-019-0061-x ↗
44. 10.1038/nm.347910.1038/nm.3479 ↗
45. 10.1016/j.neuron.2020.07.01510.1016/j.neuron.2020.07.015 ↗
46. 10.7150/thno.5257410.7150/thno.52574 ↗
47. 10.1093/nsr/nwz19910.1093/nsr/nwz199 ↗
48. 10.1021/acsnano.4c1186010.1021/acsnano.4c11860 ↗
49. 10.1002/adma.20220841410.1002/adma.202208414 ↗
50. 10.1038/s42255-023-00850-710.1038/s42255-023-00850-7 ↗
51. 10.1016/j.nanoen.2024.10943310.1016/j.nanoen.2024.109433 ↗
52. 10.1200/jco.2010.28.15_suppl.e1963010.1200/jco.2010.28.15_suppl.e19630 ↗
53. 10.1001/jama.284.21.275510.1001/jama.284.21.2755 ↗
54. 10.3390/biom910062410.3390/biom9100624 ↗
55. 10.1155/2012/46458610.1155/2012/464586 ↗
56. 10.1016/j.burns.2010.07.00510.1016/j.burns.2010.07.005 ↗
57. 10.1002/adhm.20240046210.1002/adhm.202400462 ↗
58. 10.1016/j.biomaterials.2020.12060810.1016/j.biomaterials.2020.120608 ↗
59. 10.1038/nri.2015.510.1038/nri.2015.5 ↗
60. 10.1016/S2213-8587(19)30405-X10.1016/S2213-8587(19)30405-X ↗
61. 10.1016/j.bioactmat.2024.11.00110.1016/j.bioactmat.2024.11.001 ↗
62. 10.1158/2326-6066.CIR-23-030910.1158/2326-6066.CIR-23-0309 ↗
63. 10.1016/j.lfs.2021.11925910.1016/j.lfs.2021.119259 ↗
64. 10.3389/fonc.2019.0057610.3389/fonc.2019.00576 ↗
65. 10.1016/j.canlet.2024.21709410.1016/j.canlet.2024.217094 ↗
66. 10.1136/jitc-2020-00114110.1136/jitc-2020-001141 ↗
67. 10.1136/jitc-2021-00284410.1136/jitc-2021-002844 ↗
68. 10.1186/s12951-021-01157-z10.1186/s12951-021-01157-z ↗
69. 10.1016/S0304-3959(00)00412-710.1016/S0304-3959(00)00412-7 ↗
70. 10.1109/TBME.2005.84524010.1109/TBME.2005.845240 ↗
71. 10.1002/adhm.20200079010.1002/adhm.202000790 ↗
72. 10.1016/j.pmatsci.2017.06.00310.1016/j.pmatsci.2017.06.003 ↗
73. 10.1186/s12951-024-02722-y10.1186/s12951-024-02722-y ↗
74. 10.1002/advs.20220007910.1002/advs.202200079 ↗
75. 10.1126/sciadv.adl306310.1126/sciadv.adl3063 ↗
76. 10.1016/j.bioactmat.2024.12.02510.1016/j.bioactmat.2024.12.025 ↗
77. 10.1371/journal.pone.017204310.1371/journal.pone.0172043 ↗
78. 10.1021/acsami.4c0481510.1021/acsami.4c04815 ↗
79. 10.1002/advs.20230258610.1002/advs.202302586 ↗
80. 10.1136/bmjopen-2019-03241710.1136/bmjopen-2019-032417 ↗
81. 10.1016/j.celbio.2024.10000210.1016/j.celbio.2024.100002 ↗
82. 10.1021/acs.analchem.7b0434810.1021/acs.analchem.7b04348 ↗
83. 10.1002/smll.20220414210.1002/smll.202204142 ↗
84. 10.1007/s11655-013-1650-010.1007/s11655-013-1650-0 ↗