Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells
Source abstract
Abstract
Abstract Targeting the immune system with nanoparticles (NPs) to deliver immunomodulatory molecules emerged as a solution to address intra‐tumoral immunosuppression and enhance therapeutic response. While the potential of nanoimmunotherapies in reactivating immune cells has been evaluated in several preclinical studies, the impact of drug‐free nanomaterials on the immune system remains unknown. Here, the molecular and functional response of human NK cells and pan T cells to a selection of five NPs that are commonly used in biomedical applications are characterized. After a pre‐screen to evaluate the toxicity of these nanomaterials on immune cells, ultrasmall silica‐based gadolinium (Si‐Gd) NPs and poly(lactic‐ co ‐glycolic acid) (PLGA) NPs are selected for further investigation. Bulk RNA‐sequencing and flow cytometry analysis showcase that PLGA NPs trigger a transcriptional priming toward activation in NK and pan T cells. While PLGA NPs improved NK cells anti‐tumoral functions in a cytokines‐deprived environment, Si‐Gd NPs significantly impaired T cells activation as well as functional responses to a polyclonal antigenic stimulation. Altogether, PLGA NPs are identified as an attractive strategy for reactivating the immune system of cancer patients.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Immune Cell Function and Interaction · CAR-T cell therapy research · Immunotherapy and Immune Responses
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Tumor Biomechanics lab Strasbourg 67000 France
INSERM UMR_S1109 Strasbourg 67000 France
Université de Strasbourg Strasbourg 67000 France
Fédération de Médecine Translationnelle de Strasbourg (FMTS) Strasbourg 67000 France
Équipe Labellisée Ligue Contre le Cancer Strasbourg 67000 France
Nanotranslational lab Institut de cancérologie Strasbourg Europe Strasbourg 67033 France
Strasbourg Drug Discovery and Development Institute (IMS) Strasbourg 67081 France
Plateforme GENOMAX Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg Transplantex NG Strasbourg 67000 France
Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO) IPHC UMR 7178 CNRS Université de Strasbourg Infrastructure nationale ProFI FR 2048 Strasbourg 67037 France
Service d'Immunologie Biologique Plateau Technique de Biologie Pôle de Biologie Nouvel Hôpital Civil Hôpitaux Universitaires de Strasbourg 1 Place de l'Hôpital Strasbourg 67091 France
Institut Pluridisciplinaire Hubert Curien CNRS UMR 7178 Strasbourg 67037 France
Institut Lumière Matière Université Claude Bernard – Lyon 1 CNRS UMR 5306 Villeurbanne 69622 France
Institut Universitaire de France (IUF) Paris 75231 France
Funding
HORIZON EUROPE European Research Council
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