A Micromanipulation‐Actuated Large‐Scale Screening to Identify Optimized Microphysiological Model Parameters in Skeletal Muscle Regeneration (Adv. Sci. 44/2024)

Robotic Screening for Muscle Regeneration In article number 2403622, Tao Sun, Qing Shi, and colleagues present a robotic micromanipulation approach to assess the regeneration quality of engineered muscle microfibers by measuring their viscoelasticity and contractile force. This method, which leverages micro-scale sample volumes, high precision, and automated robotic manipulation, enables large-scale screening to optimize muscle microphysiological models in complex skeletal muscle regeneration. The concept draws inspiration from the Chinese myth of “Phoenix Nirvana,” symbolizing the challenge of achieving successful muscle regeneration.