Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity
Source abstract
Abstract
Abstract Small alterations during the early stages of the innate immune response to an implant can drive large changes in adaptive immunity. Biomaterials for regenerative purposes can be engineered to modulate this immune response in beneficial ways. This study presents an innovative patch designed and functionalized to target the innate immunity at the implant site. Mannose moieties are incorporated into collagen patches, resulting in a technology called Local Immunotuning Patch (LIP), designed to directly interact with antigen presenting cells through their mannose receptor. In vitro, LIP shows anti‐inflammatory effects on bone marrow‐derived macrophages and inhibitory properties even on methicillin‐resistant bacterial strains. Subcutaneous implantation in mice reveals that LIP modulates multiple pathways related to innate and adaptive immunity, underscoring its role in shaping an immune‐engineered environment around the implant. These findings highlight the potential of this strategy to control the foreign body reaction at the implant site, making it applicable for various uses, including wound healing and surgical infection control in reconstructive procedures.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine · Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for Musculoskeletal Regeneration Houston Methodist Academic Institute Houston TX USA
Orthopedics and Sports Medicine Houston Methodist Hospital Houston TX USA
School of Medicine and Surgery Nanomedicine Center Nanomib University of Milano‐Bicocca Monza Italy
IRCCS Istituto Ortopedico Galeazzi Milan Italy
Center for Precision Environmental Health Baylor College of Medicine Houston TX USA
Human Longevity Program IRCCS San Raffaele Roma Rome Italy
Department of Human Sciences and Quality of Life Promotion San Raffaele Roma Open University Rome Italy
Center for Infectious Disease Houston Methodist Research Institute Houston TX USA
Division of Infectious Diseases and Department of Medicine Houston Methodist Hospital Houston TX USA
Department of Medicine Weill Cornell Medical College New York NY USA
Department of Medicine Section Oncology/Hematology Baylor College of Medicine Houston TX USA
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