Acoustic Wave‐Induced Stroboscopic Optical Mechanotyping of Adherent Cells
Source abstract
Abstract
Abstract In this study, a novel, high content technique using a cylindrical acoustic transducer, stroboscopic fast imaging, and homodyne detection to recover the mechanical properties (dynamic shear modulus) of living adherent cells at low ultrasonic frequencies is presented. By analyzing the micro‐oscillations of cells, whole populations are simultaneously mechanotyped with sub‐cellular resolution. The technique can be combined with standard fluorescence imaging allowing to further cross‐correlate biological and mechanical information. The potential of the technique is demonstrated by mechanotyping co‐cultures of different cell types with significantly different mechanical properties.
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Research context
OpenAlex topics: Cellular Mechanics and Interactions · Microfluidic and Bio-sensing Technologies · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Njord Centre, Department of Physics University of Oslo P.O. Box 1048 Blindern Oslo 0316 Norway
Hybrid Technology Hub University of Oslo Institute of Basic Medical Sciences P.O. Box 1110 Blindern Oslo 0317 Norway
Center for Computing in Science Education University of Oslo P.O. Box 1048 Blindern Oslo 0316 Norway
Department of Immunology and Transfusion Medicine Oslo University Hospital P.O. Box 4950, Nydalen Oslo 0424 Norway
Funding
Norges Forskningsråd
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