A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)

nDEL in Reversable Pharmacology Natural product DNA‐encoded library (nDEL) has great value in reverse pharmacology. In article number 2201258, Peixiang Ma, Hongtao Xu, Guang Yang, and co‐workers applied nDEL in a reverse pharmacology study targeting tumor necrosis factor α (TNF‐α). Several natural products, particularly kaempferol are identified to recognize and attenuate the TNF‐α signaling as that of adalimumab, and reduce mice ear inflammation. [Image: see text]