Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
Source abstract
Abstract
Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530, Elvin Blanco, Dale J. Hamilton, and co-workers demonstrate that coating mitochondria with a dextran-triphenylphosphonium (TPP) conjugate results in longer functional survival of the organelle ex vivo, increased cellular uptake, and an enhanced shift in the metabolic phenotype of cells compared to uncoated mitochondria.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Metabolism and Genetic Disorders
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Affiliations
Department of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USA
Center for Bioenergetics Houston Methodist Research Institute Houston TX 77030 USA
Department of Medicine Weill Cornell Medicine New York NY 10065 USA
Department of Physiology Weill Cornell Medicine New York NY 10065 USA
Division Endocrinology Diabetes, and Metabolism Department of Medicine Houston Methodist Hospital Houston TX 77030 USA
References
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