Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis
Source abstract
Abstract
Abstract A cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT, is presented with which can reconstruct the core molecular regulatory network model and a reversion switch based on single‐cell transcriptome data over the transition process is identified. The usefulness of REVERT is demonstrated by applying it to single‐cell transcriptome of patient‐derived matched organoids of colon cancer and normal colon. REVERT is a generic framework that can be applied to investigate various cell fate transition phenomena.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Single-cell and spatial transcriptomics · Gene Regulatory Network Analysis · Bioinformatics and Genomic Networks
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea
Research Institute National Cancer Center Goyang 10408 Republic of Korea
Department of Cancer Biomedical Science National Cancer Center Graduate School of Cancer Science and Policy Goyang 10408 Republic of Korea
Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul 03080 Republic of Korea
Funding
National Cancer Center
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