Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis (Adv. Sci. 6/2023)

Whole-Cell Biocatalysts In the article 2205580, Xinrui Zhao and co-workers report an engineered Escherichia coli strain capable of improved heme supply suitable for whole-cell P450 biocatalysis. The intracellular heme level is fine-tuned by the combined use of mutated heme-sensitive biosensor and small regulatory RNA systems.