The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023)

Systemic Lupus Erythematosus In article number 2207108, Nan Shen, Hongyan Wang, Bin Wei, and co-workers report elevated plasma levels of 7α,25-dihydroxycholesterol, but its receptor EBI2 is reduced in monocyte/macrophages from patients and mice with systemic lupus erythematosus (SLE). EBI2-deficient macrophages produce higher levels of IFN-I, chemokines and cytokines, which further recruits and activates T and B lymphocytes to exacerbate the development of SLE.