SARS‐CoV‐2 Evolution: Immune Dynamics, Omicron Specificity, and Predictive Modeling in Vaccinated Populations
Source abstract
Abstract
Abstract Host immunity is central to the virus's spread dynamics, which is significantly influenced by vaccination and prior infection experiences. In this work, we analyzed the co‐evolution of SARS‐CoV‐2 mutation, angiotensin‐converting enzyme 2 (ACE2) receptor binding, and neutralizing antibody (NAb) responses across various variants in 822 human and mice vaccinated with different non‐Omicron and Omicron vaccines is analyzed. The link between vaccine efficacy and vaccine type, dosing, and post‐vaccination duration is revealed. The classification of immune protection against non‐Omicron and Omicron variants is co‐evolved with genetic mutations and vaccination. Additionally, a model, the Prevalence Score (P‐Score) is introduced, which surpasses previous algorithm‐based models in predicting the potential prevalence of new variants in vaccinated populations. The hybrid vaccination combining the wild‐type (WT) inactivated vaccine with the Omicron BA.4/5 mRNA vaccine may provide broad protection against both non‐Omicron variants and Omicron variants, albeit with EG.5.1 still posing a risk. In conclusion, these findings enhance understanding of population immunity variations and provide valuable insights for future vaccine development and public health strategies.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: SARS-CoV-2 and COVID-19 Research · vaccines and immunoinformatics approaches · COVID-19 epidemiological studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences‐Beijing (PHOENIX Center) Beijing Institute of Lifeomics Beijing 102206 China
School of Medicine Nanjing University of Chinese Medicine Nanjing 210023 China
Department of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Academy of Military Medical Sciences Beijing 100071 China
Department of Clinical Laboratory Beijing Ditan Hospital Capital Medical University Beijing 100015 China
Emergency Medicine Clinical Research Center Beijing Chao‐Yang Hospital Capital Medical University Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020 China
Department of Clinical Laboratory Peking Union Medical College Hospital Chinese Academy of Medical Science & Peking Union Medical College Beijing 100730 China
The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China
ProteomicsEra Medical Co. Ltd. Beijing 102206 China
Funding
National Key Research and Development Program of China · Beijing Municipal Natural Science Foundation · Science and Technology Planning Project of Guangdong Province
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