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journal article·2024-02Open access

Self‐Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy

Shan Gao, Yutaka Miura, Akira Sumiyoshi, Satoshi Ohno, Keisuke Ogata, Takahiro Nomoto, Makoto Matsui, Yuto Honda, Minoru Suzuki, Megumi Iiyama, Kensuke Osada, Ichio Aoki, Nobuhiro Nishiyama

Advanced Science· Volume 11· Issue 7
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Source abstract

Abstract

Abstract Nano‐sized contrast agents (NCAs) hold potential for highly specific tumor contrast enhancement during magnetic resonance imaging. Given the quantity of contrast agents loaded into a single nano‐carrier and the anticipated relaxation effects, the current molecular design approaches its limits. In this study, a novel molecular mechanism to augment the relaxation of NCAs is introduced and demonstrated. NCA formation is driven by the intramolecular self‐folding of a single polymer chain that possesses systematically arranged hydrophilic and hydrophobic segments in water. Utilizing this self‐folding molecular design, the relaxivity value can be elevated with minimal loading of gadolinium complexes, enabling sharp tumor imaging. Furthermore, the study reveals that this NCA can selectively accumulate into tumor tissues, offering effective anti‐tumor results through gadolinium neutron capture therapy. The efficacy and versatility of this self‐folding molecular design underscore its promise for cancer diagnosis and treatment.
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Research context

Polymers

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Supramolecular Chemistry and Complexes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory for Chemistry and Life Science Tokyo Institute of Technology R1‐11, 4259 Nagatsuta‐cho, Midori‐ku Yokohama Kanagawa 226‐8503 Japan

Department of Life Science and Technology School of Life Science and Technology Tokyo Institute of Technology 4259 Nagatsuta‐cho, Midori‐ku Yokohama Kanagawa 226‐8503 Japan

Institute for Quantum Medical Science National Institutes for Quantum Science and Technology Anagawa 4‐9‐1, Inage Chiba 263‐8555 Japan

Department of Life Sciences Graduate School of Arts and Sciences The University of Tokyo 3‐8‐1 Komaba, Meguro‐ku Tokyo 153‐8902 Japan

Division of Particle Radiation Oncology Particle Radiation Oncology Research Center Institute for Integrated Radiation and Nuclear Science Kyoto University 2–1010, Asashiro‐nishi, Kumatori‐cho, Sennan‐gun Osaka 590‐0494 Japan

Innovation Center of Nanomedicine (iCONM) Kawasaki Institute of Industrial Promotion 3‐25‐14 Tonomachi Kawasaki Kanagawa 210‐0821 Japan

Funding

Japan Agency for Medical Research and Development · Japan Society for the Promotion of Science · Japan Science and Technology Agency

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