Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
Source abstract
Abstract
Abstract Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: DNA and Nucleic Acid Chemistry · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Molecular Virology Ulm University Medical Center 89081 Ulm Germany
Department of Chemistry and iNano Interdisciplinary Nanoscience Centre Aarhus University Aarhus C 8000 Denmark
Aarhus University Hospital Aarhus N 8200 Denmark
Funding
Teknologi og Produktion, Det Frie Forskningsråd · Deutsche Forschungsgemeinschaft
References (27)
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