Source abstract
Abstract
Abstract Congenital heart disease (CHD) is the major cause of morbidity/mortality in infancy and childhood. Using a mouse model to uncover the mechanism of CHD is essential to understand its pathogenesis. However, conventional 2D phenotyping methods cannot comprehensively exhibit and accurately distinguish various 3D cardiac malformations for the complicated structure of heart cavity. Here, a new automated tool based on microcomputed tomography (micro‐CT) image data sets known as computer‐assisted cardiac cavity tracking (CACCT) is presented, which can detect the connections between cardiac cavities and identify complicated cardiac malformations in mouse hearts automatically. With CACCT, researchers, even those without expert training or diagnostic experience of CHD, can identify complicated cardiac malformations in mice conveniently and precisely, including transposition of the great arteries, double‐outlet right ventricle and atypical ventricular septal defect, whose accuracy is equivalent to senior fetal cardiologists. CACCT provides an effective approach to accurately identify heterogeneous cardiac malformations, which will facilitate the mechanistic studies into CHD and heart development.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Congenital Heart Disease Studies · Congenital heart defects research · Coronary Artery Anomalies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China
State Key Laboratory of Computer Science Institute of Software Chinese Academy of Sciences Beijing 100089 China
Heart Center and Shanghai Institution of Pediatric Congenital Heart Diseases Shanghai Children's Medical Center National Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai 200127 China
State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences Shanghai 200031 China
Department of Cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Beijing Municipality
References (25)
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