Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders
Source abstract
Abstract
ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs. Cell‐free DNA (cfDNA) is not only a biomarker for various inflammatory diseases, but also a driver in innate immune responses, offering emerging diagnostic and therapeutic possibilities for inflammatory diseases. This review begins by examining immune signatures in inflammation, with particular focus on the vicious cycle between cfDNA and inflammatory responses. We then discuss cfDNA detection strategies and their clinical applications as disease biomarkers. Crucially, we highlight design principles and formulation strategies for cfDNA‐based interventions for inflammation regulation, considering physical, biochemical, and immunological properties of cfDNA. These approaches encompass advanced nanotechnologies such as drug loading, targeted delivery, inflammation‐responsive release, and microenvironment reprogramming. Subsequently, we examine cfDNA intervention strategies for precision treatment of inflammatory diseases, including inflammatory bowel diseases, rheumatoid arthritis, sepsis, periodontitis, and psoriasis. Finally, we present key insights and future perspectives, as well as discuss translational challenges and clinical considerations, thereby paving the way for innovative approaches to inflammation modulation and disease management.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Single-cell and spatial transcriptomics · Cancer Genomics and Diagnostics · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Pharmacy China Medical University Shenyang China
Department of Pharmaceutics College of Pharmacy Army Medical University Chongqing China
Department of Thoracic Surgery The First Hospital of China Medical University Shenyang China
Department of Anesthesiology The First Hospital of China Medical University Shenyang China
Funding
Wu Jieping Medical Foundation · National Natural Science Foundation of China · Innovative Research Group Project of the National Natural Science Foundation of China
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