Sulfate‐Directed Silver Dendrites with Enhanced Stability for Ultrasensitive SERS‐Based Therapeutic Drug Monitoring
Source abstract
Abstract
ABSTRACT Silver‐based surface‐enhanced Raman spectroscopy (SERS) substrates offer exceptional signal enhancement but suffer from poor long‐term stability due to oxidative degradation, limiting their utility for real‐world applications. Here, we introduce sulfate‐directed silver dendrites (s‐AgDs) as oxidation‐resistant SERS substrates with extended shelf life, reproducible signal performance, and sub‐picomolar sensitivity. Sulfate ions promote anisotropic growth and form a surface‐associated sulfate layer, resulting in dendritic morphologies with high hot‐spot density and suppressed surface oxidation. The AgDs demonstrate robust SERS performance over seven months under ambient conditions. We demonstrate translational utility by detecting five clinically relevant drugs in aqueous and blood plasma matrices with minimal pretreatment and excellent reproducibility. These results establish s‐AgDs as a stable, reproducible, and application‐ready SERS platform for point‐of‐care therapeutic drug monitoring.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Spectroscopy Techniques in Biomedical and Chemical Research · Innovative Microfluidic and Catalytic Techniques Innovation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Leibniz Institute of Photonic Technology Member of Leibniz Health Technologies Member of the Leibniz Centre For Photonics in Infection Research (LPI) Jena Germany
Helmholtz‐Zentrum Berlin für Materialien Und Energie Berlin Germany
Institute of Physical Chemistry (IPC) and Abbe Center of Photonics (ACP) Member of the Leibniz Centre For Photonics in Infection Research (LPI) Friedrich Schiller University Jena Jena Germany
Funding
Deutsche Forschungsgemeinschaft · Bundesministerium für Forschung, Technologie und Raumfahrt
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