DataVXAdvanced SciencePaper
journal article·2026-02Open access

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao

Advanced Science· Volume 13· Issue 9
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Abstract

Abstract The recent monkeypox outbreak is garnering attention, but early warning and treatment mechanisms are lacking. Owing to its rapid spread and high death rate, monkeypox must be prevented and controlled immediately. An advanced early warning system for monkeypox prevention and control is provided through aggregation‐induced emission luminogen (AIEgen)‐active monitoring and precision photodynamic therapy (PDT). This system are developed by combining a sprayable AIE@LD with a commercial liquid dressing (LD) and a pyridine‐substituted benzothiadiazole derivative possessing AIEgen properties. In vivo tests revealed that 1 min of low‐power white light PDT at 5 mW cm − 2 promoted viral eradication and lesion healing within one week. The system comprises dual optical channels that incorporate smartphone image recognition software and a cloud platform, combining image analysis, data transmission, infection monitoring, and PDT to provide a comprehensive solution for detecting, monitoring, treating, and interrupting the transmission of monkeypox. This system can considerably reduce the medical burden of monkeypox epidemics and provide innovative ideas and technological assistance for intelligent prevention and management.
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Research context

OpenAlex topics: Poxvirus research and outbreaks · Photodynamic Therapy Research Studies · Virus-based gene therapy research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute for Engineering Medicine Kunming Medical University Kunming Yunnan 650500 P. R. China

School of inspection Ningxia Medical University Yinchuan Ningxia 750004 P. R. China

BSL‐3 Laboratory (Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public Health Department of Laboratory Medicine Zhujiang Hospital，Key Laboratory of Infectious Diseases Research in South China, Southern Medical University, Ministry of Education Southern Medical University Guangzhou Guangdong 510515 P. R. China

Guangdong Basic Research Center of Excellence for Aggregate Science Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Guangdong 518172 P. R. China

Key Laboratory of Infectious Diseases Research in South China (Southern Medical University) Ministry of Education Guangzhou Guangdong 510515 P. R. China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China

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