TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease
Source abstract
Abstract
Abstract Three‐needle electroacupuncture (TNEA) has demonstrated efficacy in improving cognitive function in both Alzheimer's disease (AD) model animals and patients, although its underlying mechanism remains unclear. Here this work investigates the potential connection between cognitive‐enhancing effect and TNEA in 5×familial Alzheimer disease（5xFAD) mice model, a model characterized by Amyloid‐beta (Aβ) pathology. This work finds alterations in gamma/theta oscillations and deficits in inhibitory monosynaptic transmission in the hippocampal CA1 region of AD. Parvalbumin‐positive (PV + ) interneurons are crucial for generating gamma oscillations and modulating theta oscillation, thereby maintaining the excitation‐inhibition (E/I) balance in local neural circuits. In 5xFAD mice, TNEA modulated PV + interneuron function, enhancing gamma oscillations during quiescent states. Furthermore, during the novel object recognition test (NORT), TNEA increased theta oscillation power by strengthening presynaptic inhibitory interneurons involved in monosynaptic connections. Collectively, these findings suggest TNEA is a viable minimally invasive treatment approach for AD.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Acupuncture Treatment Research Studies · Planarian Biology and Electrostimulation · Alzheimer's disease research and treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Rehabilitation Center Tongren Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200336 China
School of Integrative Medicine Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
Yuanshen Rehabilitation Institute Shanghai Jiao Tong University School of Medicine Shanghai 200025 China
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
Department of Traditional Chinese Medicine Shanghai East Hospital Tongji University School of Medicine Shanghai 201203 China
Shanghai Key Laboratory of Flexible Medical Robotics Tongren Hospital Institute of Medical Robotics Shanghai JiaoTong University Shanghai 200336 China
Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
Funding
National Natural Science Foundation of China
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