siRNA/CS‐PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity (Adv. Sci. 40/2024)

Intestinal Fatty Acid Absorption Zhaoyan Jiang, Aihua Gu, and co-workers design the frontispiece based on an idiom ‘kill two birds with one stone’. The Chinese Great Wall background represents the intestinal wall. Sterol O-acyltransferase 2 (SOAT2) is the enzyme playing a role as the gatekeeper to control the influx of free fatty acids and cholesterol along the small intestine. Targeting inhibition of intestinal SOAT2 (one stone) can fulfill the goal to limit the uptake of both fatty acids and cholesterol (two birds) to prevent metabolic disorders induced by excessive dietary intake. More details can be found in article number 2403442.