Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Source abstract
Abstract
Abstract Autoimmune diseases, like spondyloarthritis (SpA) and rheumatoid arthritis (RA), have a high incidence and disability rate and are major diseases that seriously endanger human health. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. Under the intervention of the external environment, changes in metabolic status in vivo induce metabolite‐related post‐translational modifications (PTMs). These PTM proteins and peptides, after being presented by human leukocyte antigen (HLA) molecules of specific genotypes, can trigger autoreactive T cell expansions which are antigen‐specific and then develop into autoimmunity. Such biological processes are a great challenge to the immune tolerance status and can be an important cause of autoimmune diseases.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: T-cell and B-cell Immunology · Cytokine Signaling Pathways and Interactions · Monoclonal and Polyclonal Antibodies Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Clinical Immunology Xijing Hospital and Department of Cell Biology of National Translational Science Center for Molecular Medicine Fourth Military Medical University Xi'an Shaanxi 710032 China
State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Xi'an Shaanxi 710032 China
Xijing Innovation Research Institute Fourth Military Medical University Xi'an Shaanxi 710032 China
Funding
National Natural Science Foundation of China
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